Summary
This 2020 international collaborative study examined molecular heterogeneity in muscle-invasive bladder cancer, with specific attention to how sex influences the distribution and prevalence of distinct molecular subtypes. Drawing on a large multi-institutional cohort, the authors characterised sex-based differences in tumour molecular phenotypes, as suggested by the title, contributing to understanding of sex-specific cancer biology in this disease. The findings may inform stratified clinical approaches to bladder cancer diagnosis and treatment.
UK applicability
UK urology and oncology services may benefit from consideration of sex-specific molecular profiling in bladder cancer management protocols. However, the applicability depends on whether UK cohorts show similar molecular subtype distributions and whether molecular subtyping becomes standard clinical practice in the NHS.
Key measures
Molecular subtype classification and distribution; sex-stratified prevalence of cancer subtypes; association between sex and molecular cancer phenotype
Outcomes reported
The study examined the distribution of molecular subtypes in muscle-invasive bladder cancer across a large international cohort, stratified by sex. The research identified and characterised sex-specific differences in the prevalence and characteristics of distinct molecular cancer subtypes.
Topic tags
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