Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Metabolic basis to Sherpa altitude adaptation

James A. Horscroft, Aleksandra Kotwica, Verena Laner, James A. West, P. J. Hennis, Denny Levett, David Howard, Bernadette Fernandez, Sarah L. Burgess-Herbert, Zsuzsanna Ament, Edward T. Gilbert-Kawai, André Vercueil, Blaine Landis, Kay Mitchell, Monty Mythen, Cristina Branco, Randall S. Johnson, Martin Feelisch, Hugh Montgomery, Julian L. Griffin, Michael P. W. Grocott, Erich Gnaiger, Daniel Martín, Andrew J. Murray

Proceedings of the National Academy of Sciences · 2017

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Summary

) gene, which was enriched in the Sherpas compared with the Lowlanders. Our findings suggest that metabolic adaptations underpin human evolution to life at high altitude, and could have an impact upon our understanding of human diseases in which hypoxia is a feature.

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1073/pnas.1700527114
Catalogue ID
BFmommpb3d-vwhvt7
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