Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

Atezolizumab in Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: Outcomes by Prior Number of Regimens

José Luis Perez‐Gracia, Yohann Loriot, Jonathan E. Rosenberg, Thomas Powles, Andrea Necchi, Syed A. Hussain, Rafael Morales‐Barrera, Margitta Retz, Günter Niegisch, Ignacio Durán, Christine Théodore, Enrique Grande, Xiaodong Shen, Jingjing Wang, B. Nelson, Christina Louise Derleth, Michiel S. van der Heijden

European Urology · 2017

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Summary

This international clinical trial reports outcomes of atezolizumab monotherapy in patients with advanced or metastatic urothelial carcinoma previously treated with platinum-based chemotherapy. The analysis stratifies efficacy and safety results by the number of prior therapeutic regimens, as suggested by the title, providing evidence on how prior treatment burden may influence immunotherapy response in this patient population.

UK applicability

This oncology trial is not applicable to Vitagri's Pulse Brain focus on farming systems, soil health, and nutrient density. The record appears to have been submitted in error and should be removed from a food and agriculture research catalogue.

Key measures

Overall survival, progression-free survival, response rates, and safety outcomes stratified by prior treatment history

Outcomes reported

The study examined clinical outcomes of atezolizumab (an anti-PD-L1 immunotherapy) in patients with platinum-treated locally advanced or metastatic urothelial carcinoma, stratified by the number of prior chemotherapy regimens received.

Theme
General food systems / other
Subject
Other / interdisciplinary
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1016/j.eururo.2017.11.023
Catalogue ID
BFmommpjky-7sv4vj

Topic tags

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