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Peer-reviewed

The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer

Nick van Dijk, Alberto Gil-Jimenez, Karīna Siliņa, Maurits L. van Montfoort, Sarah Einerhand, Lars Jonkman, Charlotte S. Voskuilen, Dennis Peters, Joyce Sanders, Yoni Lubeck, Annegien Broeks, Erik Hooijberg, Daniël J. Vis, Maries van den Broek, Lodewyk F.A. Wessels, Bas W.G. van Rhijn, Michiel S. van der Heijden

Frontiers in Immunology · 2021

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Summary

T-cell-low TLS cluster after treatment. Additionally, cluster 5 (macrophage low) TLS were significantly higher after pre-operative immunotherapy, compared to untreated tumors. We also compared the immune cell composition and maturation stages between superficial (submucosal) and deeper TLS, revealing that superficial TLS had more pronounced T-helper cells and enrichment of early TLS than TLS located in deeper tissue. Furthermore, superficial TLS displayed a lower fraction of secondary follicle like TLS than deeper TLS. Taken together, our results provide a detailed quantitative overview of the tumor immune landscape in UC, which can provide a basis for further studies.

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.3389/fimmu.2021.793964
Catalogue ID
BFmommpjky-v1y7jj
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