Summary
This nationwide population-based study investigated outcomes in Dutch patients with clinically node-positive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy. The research examined the relationship between pathological downstaging following induction chemotherapy and long-term survival, as suggested by the study design and cohort approach employed between 2005–2016.
UK applicability
The findings are relevant to UK urological oncology practice and may inform discussion of neoadjuvant chemotherapy protocols in the NHS, though treatment algorithms and patient populations may differ slightly between Dutch and UK settings.
Key measures
Pathological downstaging rate, overall survival, cancer-specific survival, recurrence-free survival
Outcomes reported
The study examined pathological downstaging (reduction in cancer stage after chemotherapy) and overall survival in patients with clinically node-positive bladder cancer treated with induction chemotherapy followed by radical cystectomy. Population-based survival and staging outcomes were analysed in a nationwide Dutch cohort.
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