Bas W.G. van Rhijn, Laura S. Mertens, Roman Mayr, Peter J. Boström, Francisco X. Real, Ellen C. Zwarthoff, Joost L. Boormans, Cheno Abas, Geert J.L.H. van Leenders, S. A. Gotz, Katrin Hippe, Simone Bertz, Y. Neuzillet, Joyce Sanders, Annegien Broeks, Michiel S. van der Heijden, Michael A.S. Jewett, Mirari Márquez, Robert Stoehr, Alexandre R. Zlotta, Markus Eckstein, Yanish Soorojebally, Hossain Roshani, Maximilian Burger, Wolfgang Otto, François Radvanyi, Nanor Sirab, Damien Pouessel, Bernd Wullich, Theodorus van der Kwast, Núria Malats, Arndt Hartmann, Yves Allory, Tahlita C.M. Zuiverloon

doi:10.1016/j.eururo.2020.07.002

Summary

This multi-institutional cohort study investigated FGFR3 mutation prevalence and expression patterns in bladder cancer patients treated by radical cystectomy, as suggested by the title. The findings appear intended to inform clinical decision-making regarding patient selection for anti-FGFR3 targeted therapies. The work is oncology-focused rather than relevant to food systems, farming or soil health.

UK applicability

This is a basic oncology research study on bladder cancer molecular biology and has no direct applicability to UK farming systems, soil health or nutritional outcomes. It does not fall within Vitagri's Pulse Brain remit.

Key measures

FGFR3 mutation status, FGFR3 protein expression levels, clinicopathological outcomes in radical cystectomy patients

Outcomes reported

The study examined FGFR3 mutation status and protein expression levels in a large cohort of bladder cancer patients who underwent radical cystectomy, with implications for patient selection for anti-FGFR3 targeted therapies.

Theme: General food systems / other
Subject: Other / interdisciplinary
Study type: Research
Study design: Observational cohort
Source type: Peer-reviewed study
Status: Published
Geography: International
System type: Human clinical
DOI: 10.1016/j.eururo.2020.07.002
Catalogue ID: BFmor3gdee-8dc7lg

Topic tags

bladder cancer fgfr3 mutation targeted therapy radical cystectomy molecular profiling

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FGFR3 Mutation Status and FGFR3 Expression in a Large Bladder Cancer Cohort Treated by Radical Cystectomy: Implications for Anti-FGFR3 Treatment?†