Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

Redefining adequate margins in oral squamous cell carcinoma: outcomes from close and positive margins

Prateek Jain, Rajeev Sharan, Kapila Manikantan, Gary M. Clark, Sanjoy Chatterjee, Indranil Mallick, Paromita Roy, Pattatheyil Arun

European Archives of Oto-Rhino-Laryngology · 2020

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Summary

This clinical outcome study, published in a leading otolaryngology journal, investigated whether conventional surgical margin definitions require revision in oral squamous cell carcinoma management. The authors examined patient cohorts with close and positive surgical margins to assess whether current margin adequacy standards optimally predict clinical outcomes. The work contributes to an ongoing clinical dialogue on margin thresholds in head and neck cancer surgery.

UK applicability

UK head and neck surgical oncology practice would benefit from these margin definitions if they inform national guidelines (such as those of the British Association of Head and Neck Oncologists); however, applicability depends on whether the study cohort demographics and treatment protocols align with NHS practice.

Key measures

Recurrence-free survival, overall survival, locoregional control, margin distance classification

Outcomes reported

The study examined recurrence rates, survival outcomes, and disease control in oral squamous cell carcinoma patients stratified by surgical margin status (close versus positive margins). As suggested by the title, the research appears to reassess conventional margin adequacy thresholds in head and neck cancer surgery.

Theme
General food systems / other
Subject
Other / interdisciplinary
Study type
Research
Study design
Observational cohort
Source type
Peer-reviewed study
Status
Published
System type
Human clinical
DOI
10.1007/s00405-019-05779-w
Catalogue ID
BFmor3gfca-5zyz31

Topic tags

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