Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Balanced Crystalloid versus Saline in Adults with Traumatic Brain Injury: Secondary Analysis of a Clinical Trial

Sarah Lombardo, Michael C. Smith, Matthew W. Semler, Li Wang, Mary Lynn Dear, Christopher J. Lindsell, Robert E. Freundlich, Oscar D. Guillamondegui, Wesley H. Self, Todd W. Rice, for the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) Investigators and Vanderbilt Learning Healthcare System Platform Investigators, Matthew W. Semler, Wesley H. Self, Jonathan P. Wanderer, Jesse M. Ehrenfeld, Li Wang, Daniel W. Byrne, Joanna L. Stollings, Avinash B. Kumar, Christopher G. Hughes, Antonio Hernandez, Oscar D. Guillamondegui, Addison K. May, Liza Weavind, Jonathan D. Casey, Edward D. Siew, Andrew Shaw, Gordon R. Bernard, Todd W. Rice, Ryan M. Brown, Michael J. Noto, Henry J. Domenico, William T. Costello, Jayme Gibson, Emily Holcombe, Mias Pretorius, A. Scott McCall, Leanne Atchison, Debra F. Dunlap, Matthew Felbinger, Susan Hamblin, Molly Knostman, Kelli Rumbaugh, Mark D. Sullivan, Julie Y. Valenzuela, Jason B. Young, David P. Mulherin, Fred R. Hargrove, Gordon R. Bernard, Robert S. Dittus, Shon Dwyer, Robert E. Freundlich, Cheryl L. Gatto, Frank E. Harrell, Paul A. Harris, Tina V. Hartert, Jim Hayman, Catherine H. Ivory, K. Johnson, Ruth Kleinpell, Sunil Kripalani, Christopher J. Lindsell, Lee Ann Liska, Patrick Luther, Jay Morrison, Thomas Nantais, Mariann R. Piano, Jill M. Pulley, Kris Rehm, Todd W. Rice, Russell L. Rothman, Matthew W. Semler, Robin Steaban, Philip Walker, Consuelo H. Wilkins, Adam Wright, Autumn D. Zuckerman

Journal of Neurotrauma · 2022

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Summary

= 0.04). Overall, balanced crystalloids were associated with worse discharge disposition in critically injured patients with TBI compared with saline. The confidence intervals cannot exclude a clinically relevant increase in mortality when balanced crystalloids are used for patients with TBI.

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Human clinical
DOI
10.1089/neu.2021.0465
Catalogue ID
BFmoso8xrl-7yln0f
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