Pulse Brain · Growing Health Evidence Index
Tier 2 — RCT / large cohortPeer-reviewed

Effects of financial incentives on volunteering for clinical trials: A randomized vignette experiment

Leonard Bickman, Henry J. Domenico, Daniel W. Byrne, Rebecca N Jerome, Terri Edwards, Mary Stroud, Laurie Lebo, Kyle McGuffin, Consuelo H. Wilkins, Paul A. Harris

Contemporary Clinical Trials · 2021

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Summary

This randomised vignette experiment investigated how financial incentives affect recruitment into clinical trials, a methodological question relevant to trial governance and research ethics. The study, conducted by researchers at Vanderbilt University and collaborators, examined participant decision-making across different incentive levels using experimental scenarios. As suggested by the title and journal context, the findings likely inform best practice in trial recruitment without unduly influencing participation through excessive compensation.

UK applicability

UK research ethics governance (via NRES and REC frameworks) similarly grapples with appropriate incentive levels in trial recruitment. These findings may be relevant to UK trial design, though differences in NHS recruitment infrastructure and ethical guidelines should be considered when adapting recommendations.

Key measures

Participant willingness to volunteer for clinical trials under varying financial incentive scenarios; recruitment decision outcomes in randomised vignette experiment

Outcomes reported

The study examined how different levels of financial incentives influence individuals' willingness to participate in clinical trials using a vignette-based experimental design.

Theme
Policy, governance & rights
Subject
Other / interdisciplinary
Study type
Research
Study design
RCT
Source type
Peer-reviewed study
Status
Published
Geography
United States
System type
Human clinical
DOI
10.1016/j.cct.2021.106584
Catalogue ID
BFmoso8xrl-aszn55

Topic tags

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