Pulse Brain · Growing Health Evidence Index
Tier 3 — Observational / field trialPeer-reviewed

Rapid generation of potent antibodies by autonomous hypermutation in yeast

Alon Wellner, Conor McMahon, Morgan S. A. Gilman, Jonathan R. Clements, Sarah A. Clark, Kianna M. Nguyen, Ming Hua Ho, Vincent J. Hu, Jung-Eun Shin, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Laura M. Wingler, Aaron G. Schmidt, Debora S. Marks, Jonathan Abraham, Andrew C. Kruse, Chang C. Liu

Nature Chemical Biology · 2021

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Summary

This 2021 Nature Chemical Biology paper describes a biotechnology platform enabling rapid autonomous hypermutation in yeast cells to generate potent antibodies. The work, as suggested by the title and journal scope, represents a methodological advance in synthetic antibody development relevant to immunological research. The direct relevance to agricultural food systems and soil health is not apparent from the metadata provided.

UK applicability

This is a fundamental immunology and synthetic biology paper with limited direct applicability to UK agricultural or soil health policy and practice. It may have indirect relevance to future agricultural biotechnology or food safety applications, but such connections would require examination of the full text.

Key measures

Antibody potency, generation speed, hypermutation efficiency in yeast cells

Outcomes reported

The study reports development of a yeast-based platform for rapid generation of potent antibodies through autonomous hypermutation mechanisms. As suggested by the title, the work measured antibody potency and generation speed relative to conventional methods.

Theme
General food systems / other
Subject
Other / interdisciplinary
Study type
Research
Study design
Research
Source type
Peer-reviewed study
Status
Published
Geography
United States
System type
Laboratory / in vitro
DOI
10.1038/s41589-021-00832-4
Catalogue ID
BFmou2m3wf-wk013d

Topic tags

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