Summary
This field trial in two Tanzanian districts evaluated the efficacy of five trematocides against concurrent Fasciola gigantica and amphistome infections in cattle using faecal egg count reduction tests. Nitroxynil, oxyclozanide, closantel and triclabendazole achieved 100% efficacy against F. gigantica by day 14, whilst albendazole demonstrated reduced efficacy (49–89% FECR by day 14 depending on district). Oxyclozanide was the only drug effective against amphistomes (99% FECR), indicating variable drug performance and potential anthelmintic resistance in certain populations.
UK applicability
The UK does not have endemic Fasciola gigantica or significant amphistome infections in cattle; however, these findings on anthelmintic resistance mechanisms and drug efficacy assessment methods may inform monitoring strategies for native Fasciola hepatica fluke in UK livestock and contribute to global understanding of trematode resistance patterns.
Key measures
Faecal egg count reduction (FECR%) at days 7, 14 and 28 post-treatment; patent infection status
Outcomes reported
The study assessed the efficacy of five different trematocides (albendazole, nitroxynil, oxyclozanide, closantel and triclabendazole) against Fasciola gigantica and amphistome infections in cattle using faecal egg count reduction tests at 7, 14 and 28 days post-treatment. Efficacy was measured as the percentage reduction in faecal egg counts compared to untreated controls.
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