Summary
This narrative review, published in Phytotherapy Research (2025), synthesises current evidence on plant-derived bioactive compounds and their capacity to modulate the mechanistic target of rapamycin (mTOR) signalling pathway, which plays a central role in cancer cell proliferation, survival, and metabolism. The authors likely survey a range of phytochemicals — such as flavonoids, alkaloids, and polyphenols — assessing their potential as adjunct or alternative oncological agents. The review contributes to the growing body of literature exploring plant-based interventions at the molecular level in cancer biology.
UK applicability
While the review is not geographically specific, its findings are broadly applicable to UK cancer research and integrative oncology practice, particularly given increasing NHS and research council interest in plant-derived therapeutic compounds and nutraceutical interventions.
Key measures
mTOR pathway modulation; anti-tumour activity of plant bioactive compounds; molecular mechanisms of action
Outcomes reported
The review examines how plant-derived bioactive compounds interact with the mTOR signalling pathway to modulate oncological disorders, likely cataloguing compounds with inhibitory or regulatory effects on tumour-associated mTOR activity.
Topic tags
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