Summary
This laboratory study describes the development and optimisation of a nanoemulsion formulation derived from ethanolic extract of Centella asiatica (NanoSECA) using D-optimal mixture design methodology. The authors employed statistical experimental design to identify optimal ratios of formulation excipients that enhance biopharmaceutical properties and blood-brain barrier permeability. The work contributes to phytopharmaceutical nanotechnology research, with potential application to improving cerebral bioavailability of traditionally used botanical extracts.
UK applicability
This laboratory formulation research has limited direct applicability to UK farming or food systems policy. However, findings may inform future development of phytopharmaceutical delivery systems for cognitive health applications in the UK nutraceutical and pharmaceutical sectors.
Key measures
Nanoemulsion particle size, zeta potential, encapsulation efficiency, in vitro blood-brain barrier permeability, formulation composition ratios
Outcomes reported
The study reports the optimised nanoemulsion formulation parameters of ethanolic Centella asiatica extract achieved through D-optimal mixture design. The work measured biopharmaceutical properties and permeability characteristics relevant to blood-brain barrier penetration.
Topic tags
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