Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryConference paper

Proceedings of the National Cancer Institute Workshop on combining immunotherapy with radiotherapy: challenges and opportunities for clinical translation

Zachary S. Morris, Sandra Demaria, Arta M. Monjazeb, Silvia C. Formenti, Ralph R. Weichselbaum, James Welsh, Heiko Enderling, Jonathan D. Schoenfeld, Joshua Brody, Heather M. McGee, Michele Mondini, Michael S. Kent, Kristina H. Young, Lorenzo Galluzzi, Sana D. Karam, Willemijn S.M.E. Theelen, Joe Y. Chang, Mai Anh Huynh, Adi Daib, Sean P. Pitroda, Caroline Chung, Raphaël Serre, Clemens Grassberger, Jie Deng, Quaovi H. Sodji, Anthony T. Nguyen, Ravi B. Patel, Simone Krebs, Anusha Kalbasi, Caroline P. Kerr, Claire Vanpouille‐Box, Logan V. Vick, Todd A. Aguilera, Irene M. Ong, Fernanda Herrera, Hari Menon, Dee Dee Smart, Jalal Ahmed, Robyn D. Gartrell, Christina L. Roland, Fatemeh Fekrmandi, Binita Chakraborty, Eric H. Bent, Tracy J. Berg, Alan D. Hutson, Samir N. Khleif, Andrew G. Sikora, Lawrence Fong

The Lancet Oncology · 2025

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Summary

This National Cancer Institute workshop proceedings, published in The Lancet Oncology in 2025, brings together leading radiation and immuno-oncology researchers to evaluate the scientific rationale, preclinical evidence and clinical evidence for combining immunotherapy with radiotherapy. The document appears to address key barriers to clinical translation, including patient selection, sequencing of treatments, toxicity management and biomarker-driven trial design. As a consensus document from a multi-institutional workshop, it serves as a resource for standardising approaches to combination immunoradiotherapy rather than reporting primary research findings.

UK applicability

This international expert consensus on immunotherapy–radiotherapy combination strategies is directly applicable to UK oncology practice and NHS treatment protocols. The proceedings may inform development of UK clinical trial frameworks and radiotherapy guidelines, particularly for cancer centres conducting early-phase combination trials.

Key measures

Not applicable — this is a workshop proceedings document synthesising expert consensus rather than reporting empirical metrics.

Outcomes reported

The proceedings document discusses challenges, opportunities and clinical translation pathways for combining immunotherapy with radiotherapy in cancer treatment. The workshop report synthesises expert perspectives on mechanistic understanding, trial design and practical implementation of combined modality approaches.

Theme
General food systems / other
Subject
Other / interdisciplinary
Study type
Narrative Review
Study design
Narrative review
Source type
Conference paper
Status
Published
Geography
United States
System type
Human clinical
DOI
10.1016/s1470-2045(24)00656-9
Catalogue ID
SNmoh0dtgr-xs9jte

Topic tags

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