Summary
This narrative review examines the historical development of understanding DNA damage repair in cancer biology and its therapeutic targeting. The authors synthesise mechanistic pathways underlying DNA damage response abnormalities and discuss clinical drugs and trial strategies, whilst proposing two novel conceptual frameworks ('environmental gear selection' and 'DNA damage baseline drift') to advance targeted cancer therapy development. The work aims to bridge basic mechanisms with clinical application and identify emerging druggable targets.
UK applicability
The review's focus on molecular mechanisms and clinical translation of cancer therapeutics has direct relevance to UK oncology research and drug development. However, as a mechanistic review without agricultural or nutritional focus, it does not directly address UK farming, soil health or food system outcomes.
Key measures
Not applicable; narrative review synthesising mechanistic pathways and clinical translation of DNA damage repair in cancer therapy
Outcomes reported
The review synthesises historical perspectives on DNA damage repair pathways and their role in cancer development and treatment. It discusses clinical therapeutic drugs targeting DNA damage repair and proposes two novel hypotheses—'environmental gear selection' and 'DNA damage baseline drift'—to inform future targeted cancer therapy strategies.
Topic tags
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