Summary
This consensus statement, synthesised from a meeting of CAF biology experts, provides a comprehensive framework for understanding cancer-associated fibroblasts as key components of the tumour microenvironment. The authors review CAF origin, heterogeneity, and diverse functions including matrix remodelling and cell signalling, whilst acknowledging significant challenges in targeting CAFs therapeutically without eliminating beneficial antitumorigenic functions. The framework is intended to guide future research and therapeutic development targeting this critical cell type.
UK applicability
This paper is not directly applicable to UK agriculture, soils, or farming systems, as it addresses fundamental tumour biology rather than food systems or agriculture. However, understanding CAF biology may inform future translational cancer research conducted in UK institutions.
Key measures
Conceptual framework for CAF classification, origin mechanisms, and functional heterogeneity; synthesis of CAF signalling interactions with cancer cells and immune cells; discussion of therapeutic targeting approaches
Outcomes reported
This consensus statement synthesises current knowledge on cancer-associated fibroblasts (CAFs), their origins, heterogeneity, and functions within the tumour microenvironment. The paper presents a framework for advancing understanding of CAF biology to optimise therapeutic strategies against cancer.
Topic tags
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