Summary
This Nature Reviews Genetics article provides a comprehensive overview of the genetic basis of human ageing, synthesising evidence from population studies, twin analyses, and molecular biology. The authors discuss key genetic variants associated with longevity and age-related disease, as well as emerging understanding of epigenetic and cellular mechanisms underlying ageing. The review situates genetics within the broader context of intrinsic and environmental drivers of ageing.
UK applicability
The genetic findings are broadly applicable to UK populations, though the authors note that environmental and lifestyle factors substantially modify genetic predisposition. UK public health policy on ageing may benefit from understanding heritable components of age-related disease, though intervention priorities remain focused on modifiable risk factors.
Key measures
Genetic associations with lifespan, age-related disease susceptibility, epigenetic markers, molecular ageing pathways
Outcomes reported
The paper synthesises evidence on genetic variants and molecular mechanisms associated with human ageing and longevity. It reviews how genomic and epigenetic factors influence age-related physiological decline and lifespan.
Topic tags
Dig deeper with Pulse AI.
Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.