Summary
This paper presents the revised ARRIVE 2.0 guidelines, an updated framework for transparent reporting of in vivo animal experiments developed to improve reproducibility in biomedical research. The accompanying explanation and elaboration document provides detailed rationale, evidence, and practical examples for each of the 21 reporting items, alongside guidance on study design and conduct best practice. Though the original ARRIVE guidelines (2010) achieved widespread endorsement, adoption impact on publication transparency remained limited; the 2.0 revision aims to address this through enhanced usability and implementation support.
UK applicability
These guidelines are relevant to UK researchers conducting or publishing animal research across all academic institutions and journals. Adoption by UK funding bodies (such as UKRI) and journals would improve the reproducibility and transparency of biomedical research conducted in the United Kingdom.
Key measures
Reporting completeness and transparency across 21 standardised items covering study design, conduct, analysis, and publication aspects of animal research
Outcomes reported
The paper presents revised ARRIVE 2.0 guidelines with 21 items designed to improve transparent reporting of in vivo animal experiments. It provides elaboration, rationale, and examples of good reporting practice for each guideline item.
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