Summary
This narrative review synthesises current evidence on microRNA-185's multifaceted roles in human cancer pathogenesis, examining its expression patterns, molecular targets, and dysregulation in malignant transformation. The authors argue that miR-185 functions as either an oncomiR or tumour suppressor depending on cancer type and cellular context, with implications for understanding small regulatory RNA biology in oncology. The review contributes to knowledge of miR-185-mediated mechanisms in tumorigenesis and suggests potential therapeutic targeting strategies, though clinical translation remains to be established.
UK applicability
As a mechanistic review of molecular pathways in cancer biology, the findings are broadly applicable to UK cancer research and oncology practice. However, the review does not directly address agricultural or nutritional pathways to cancer prevention, and applicability to UK farming systems or food-based interventions is limited.
Key measures
microRNA-185 expression levels, target gene identification, effects on cell proliferation, apoptosis, invasion and metastasis in various cancer contexts
Outcomes reported
The review synthesised evidence on microRNA-185 expression patterns, molecular targets, and dysregulation across human cancer types. The authors examined miR-185's context-dependent roles as either an oncomiR or tumour suppressor and implications for cancer diagnosis and therapeutic intervention.
Topic tags
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