Summary
This 2023 handbook chapter by Hriţcu and Cioancă reviews the role of animal models in cancer therapeutic research, critically examining their utility for identifying molecular targets alongside their limitations in translating findings to clinical outcomes. The authors appear to weigh the scientific value of various animal model systems against practical and ethical drawbacks. The chapter contributes to ongoing discourse on model organism selection and the adequacy of preclinical research frameworks in oncology.
UK applicability
This review is relevant to UK-based cancer research institutions and regulatory bodies (including the MHRA and NC3Rs) involved in licensing and overseeing animal models in drug development. The discussion of model limitations and translational gaps may inform national refinement of animal research governance and the adoption of alternative methodologies.
Key measures
Comparative assessment of animal model adequacy, translational success rates, and ethical considerations in cancer therapeutic target validation
Outcomes reported
The chapter examines the utility and limitations of various animal model systems for identifying cancer therapeutic molecular targets and their capacity to predict clinical outcomes. It appears to assess both the scientific strengths and practical/ethical drawbacks of different model organisms in oncological research.
Topic tags
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