Summary
This 2022 handbook chapter by Hriţcu and Cioancă provides a critical review of animal models used in cancer research, focusing on their value in identifying and validating therapeutic molecular targets. The authors examine both the practical necessity of in vivo preclinical validation and the significant biological complexities and limitations that arise when translating findings from model organisms to human clinical settings. The work appears to address a persistent tension in oncology: the need for robust animal-based target discovery against the acknowledged inadequacy of cross-species extrapolation.
UK applicability
This is a methodological review of laboratory-based cancer research practices and does not directly address UK farming, food systems, or nutritional outcomes. Its applicability to UK policy or agricultural practice is minimal, though insights into translational biology may inform UK pharmaceutical or biomedical research governance.
Key measures
Comparative assessment of animal model systems (molecular fidelity, predictive validity, target translatability); utility and drawbacks in oncology drug development
Outcomes reported
The chapter reviews the utility and limitations of animal models in identifying therapeutic molecular targets for cancer, with emphasis on the adequacy of cross-species biological translation to human clinical application.
Topic tags
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