Summary
This 2023 narrative review by Quezada and López-Bergami examines the molecular signalling pathways activated by the ROR1 receptor in cancer cells, published in Cellular Signalling. The authors consolidate current understanding of how ROR1 engagement triggers intracellular cascades that promote tumour cell survival and proliferation, with implications for cancer aetiology and potential therapeutic targeting. The work is foundational oncology research with no direct connection to agricultural, soil health, nutritional, or farming systems contexts.
UK applicability
This paper addresses fundamental cancer cell biology and is not applicable to UK agricultural policy, farming practice, soil management, or food system development. It may have indirect relevance to UK cancer research and therapeutic development programmes, but lies outside the scope of food systems and agricultural sustainability.
Key measures
ROR1-mediated signalling pathway activation; intracellular cascade mechanisms; tumour cell survival and proliferation endpoints
Outcomes reported
The review synthesises evidence on intracellular signalling cascades activated by ROR1 receptor engagement in cancer cells. The study examined molecular mechanisms linking ROR1 activation to tumour cell survival and proliferation.
Topic tags
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