Summary
This review synthesises current advances in metabolomic analytical chemistry, focusing on innovative sample preparation, liquid and gas chromatography, and high-resolution mass spectrometry coupled with emerging techniques such as ion-mobility and tandem MS. The authors discuss how these complementary analytical platforms enhance detection of low-abundance metabolites and expand the depth of metabolic pathway analysis. The paper highlights the translational potential of metabolomics for biomarker discovery, clinical diagnostics, and personalised medicine, indicating its growing role in human health research.
UK applicability
The analytical methods and platforms reviewed are applicable to UK research institutions and clinical laboratories seeking to implement or upgrade metabolomic capabilities for disease research and precision medicine. However, the review addresses general analytical chemistry principles rather than UK-specific agricultural, nutritional, or public health contexts.
Key measures
Not applicable to a methodological review; the paper discusses analytical performance metrics such as sensitivity, selectivity, and throughput of metabolomic platforms
Outcomes reported
The paper reviews innovative analytical strategies and technological advances for expanding metabolome coverage, including sample preparation, chromatographic separation, and mass spectrometry techniques. It emphasises the application of these methods to biomarker discovery, disease diagnostics, and personalised medicine in clinical settings.
Topic tags
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