Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

Eleonora Porcu, Marie C. Sadler, Kaido Lepik, Chiara Auwerx, Andrew R. Wood, Antoine Weihs, Maroun Bou Sleiman, Diogo M. Ribeiro, Stefania Bandinelli, Toshiko Tanaka, Matthias Nauck, Uwe Völker, Olivier Delaneau, Andres Metspalu, Alexander Teumer, Timothy M. Frayling, Federico Santoni, Alexandre Reymond, Zoltán Kutalik

Nature Communications · 2021

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Summary

), but not detectably with expression-to-trait effects. Our results demonstrate that studies comparing the transcriptome of diseased and healthy subjects are more prone to reveal disease-induced gene expression changes rather than disease causing ones.

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1038/s41467-021-25805-y
Catalogue ID
SNmoj1yk7l-jrp4a7
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