Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Alcohol consumption and risks of more than 200 diseases in Chinese men

Pek Kei Im, Neil Wright, Ling Yang, Ka Hung Chan, Yiping Chen, Yu Guo, Huaidong Du, Xiaoming Yang, Daniel Avery, Shaojie Wang, Canqing Yu, Jun Lv, Robert Clarke, Junshi Chen, Rory Collins, Robin Walters, Richard Peto, Liming Li, Zhengming Chen, Iona Y. Millwood, China Kadoorie Biobank Collaborative Group, Chen Wang, Maxim Barnard, Derrick Bennett, Ruth Boxall, Johnathan Clarke, Ahmed Edris Mohamed, Hannah Fry, Simon Gilbert, Andri Iona, Maria Kakkoura, Christiana Kartsonaki, Hubert Lam, Kuang Lin, James H. Liu, Mohsen Mazidi, Sam Morris, Qunhua Nie, Alfred Pozarickij, Paul Ryder, Saredo Said, Dan Schmidt, Becky Stevens, Iain Turnbull, Baihan Wang, Lin Wang, Pang Yao, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Pei Pei, Dianjianyi Sun, Naying Chen, Duo Liu, Zhenzhu Tang, Ningyu Chen, Qilian Jiang, Jian Lan, Mingqiang Li, Yun Liu, Fanwen Meng, Jinhuai Meng, Rong Pan, Yulu Qin, Ping Wang, Sisi Wang, Liuping Wei, Liyuan Zhou, Caixia Dong, Pengfei Ge, Xiaolan Ren, Zhongxiao Li, Enke Mao, Tao Wang, Hui Zhang, Xi Zhang, Jinyan Chen, Ximin Hu, Xiaohuan Wang, Zhendong Guo, Huimei Li, Yilei Li, Min Weng, Shukuan Wu, Shichun Yan, Mingyuan Zou, Xue Zhou, Ziyan Guo, Quan Kang, Yanjie Li, Bo Yu, Qinai Xu, Liang Chang, Lei Fan, Shixian Feng, Ding Zhang, Gang Zhou, Yulian Gao, Tianyou He

Nature Medicine · 2023

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Summary

Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2- rs671 and ADH1B- rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defined by the World Health Organization as alcohol-related, such as cataract (n = 2,028; hazard ratio 1.21; 95% confidence interval 1.09-1.33, per 280 g per week) and gout (n = 402; 1.57, 1.33-1.86). Genotype-predicted mean alcohol intake was positively associate

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1038/s41591-023-02383-8
Catalogue ID
SNmoj1yrjs-tyqd78
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