Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities

Isabelle M. McGrath, Grant W. Montgomery, Sally Mortlock

Human Reproduction Update · 2023

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Summary

BACKGROUND: Endometriosis remains a poorly understood disease, despite its high prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of multiple other traits in women with endometriosis is becoming increasingly apparent through epidemiological data. Genetic studies offer a method of investigating these comorbid relationships through the assessment of causal relationships with Mendelian randomization (MR), as well as identification of shared genetic variants and genes involved across traits. This has the capacity to identify risk factors for endometriosis as well as provide insight into the aetiology of disease. OBJECTIVE AND RATIONALE: We aim to review the current literature assessing the relationship between endometriosis and other traits using genomic data

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1093/humupd/dmad009
Catalogue ID
SNmoj1yt99-xinf21
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