Summary
This large-scale genome-wide association study analysed 2,068 traits in nearly 636,000 genetically diverse US Veterans, identifying over 13,600 genomic risk loci and fine-mapping causal variants at over 6,300 signals. A substantial proportion of novel genetic insights (approximately one-third of fine-mapped variants) emerged from non-European participants, demonstrating the scientific value of population diversity in genetic studies and providing an extensive atlas of trait–genetic associations.
UK applicability
The genetic architecture findings may be broadly applicable to UK populations with similar ancestry composition, though direct translation requires consideration of ethnically stratified UK cohorts. The emphasis on diverse population representation could inform future UK biobank studies and clinical genomics practice.
Key measures
Genomic risk loci count; fine-mapped causal variants; trait associations across diverse population groups; number of loci identified exclusively in non-European populations
Outcomes reported
Genome-wide associations were identified for 2,068 traits in 635,969 diverse US Veterans participants, revealing 13,672 genomic risk loci. Fine-mapping identified causal variants at 6,318 signals, with one-third discovered in non-European populations.
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