Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Association of Dual Antiplatelet Therapy With Ticagrelor With Vein Graft Failure After Coronary Artery Bypass Graft Surgery

Sigrid Sandner, Björn Redfors, Dominick J. Angiolillo, Katia Audisio, Stephen E. Fremes, Paul W.A. Janssen, Alexander Kulik, Roxana Mehran, Joyce Peper, Marc Ruel, Jacqueline Saw, Giovanni Soletti, Andrew Starovoytov, Jurriën M. ten Berg, Laura M. Willemsen, Qiang Zhao, Yunpeng Zhu, Mario Gaudino

JAMA · 2022

Read source ↗ All evidence

Summary

Importance: The role of ticagrelor with or without aspirin after coronary artery bypass graft surgery remains unclear. Objective: To compare the risks of vein graft failure and bleeding associated with ticagrelor dual antiplatelet therapy (DAPT) or ticagrelor monotherapy vs aspirin among patients undergoing coronary artery bypass graft surgery. Data Sources: MEDLINE, Embase, and Cochrane Library databases from inception to June 1, 2022, without language restriction. Study Selection: Randomized clinical trials (RCTs) comparing the effects of ticagrelor DAPT or ticagrelor monotherapy vs aspirin on saphenous vein graft failure. Data Extraction and Synthesis: Individual patient data provided by each trial were synthesized into a combined data set for independent analysis. Multilevel logistic r

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1001/jama.2022.11966
Catalogue ID
SNmojj1oee-t232i2
Pulse AI · ask about this record

Dig deeper with Pulse AI.

Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.

What does the evidence say about Other / interdisciplinary?→How does this finding apply in a UK context?→What are the most cited records on this topic?→

Related evidence