Summary
This comprehensive narrative review examines polymeric nanoparticles as drug delivery vehicles, addressing their exceptional control over physiochemical properties and capacity to navigate biological barriers whilst releasing cargo in response to stimuli. The authors survey nanoparticle designs, polymer bases, and preparation methods, then evaluate performance against multiple disease states. The review identifies why, despite significant technical advantages, polymeric nanoparticles remain minimally represented in clinical application and outlines crucial challenges for future clinical potential.
UK applicability
As a nanomedicine review focused on therapeutic drug delivery systems rather than agricultural or food systems, this paper has limited direct applicability to UK farming, soil health, or food-systems policy. It may inform UK pharmaceutical development and biomedical research strategy, but sits outside the remit of agricultural innovation.
Key measures
Physiochemical properties (size, shape, architecture, charge, surface functionality); cargo encapsulation and release kinetics; biological barrier navigation; therapeutic efficacy against cancer, viral and bacterial infections; clinical translation barriers
Outcomes reported
The review synthesises current knowledge on polymeric nanoparticle design, preparation methods, and performance against multiple disease states including cancer, viral and bacterial infections. It evaluates the advantages and key challenges limiting wider clinical adoption of these drug delivery systems.
Topic tags
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