Summary
This narrative review examines the application of synthetic biology and metabolic engineering to engineer microbial cell factories for producing terpenoid food ingredients. The authors synthesise current approaches to optimising heterologous pathways, including precursor availability, overcoming metabolic constraints, and integrating synthetic regulatory circuits, whilst emphasising the critical importance of genetic stability for commercial-scale production.
UK applicability
The biotechnological approaches described have potential application in the United Kingdom's growing fermentation and biomanufacturing sector, particularly for producing food-grade terpenoid flavours and additives locally. However, the review is technology-focused and does not address regulatory pathways, cost competitiveness, or integration with UK food industry infrastructure.
Key measures
Production efficiency of heterologous terpenoid pathways; optimisation of precursor supply; genetic and metabolic stability; scalability for commercial fermentation
Outcomes reported
The paper reviews synthetic biology and metabolic engineering approaches for optimising microbial production of terpenoids used as food ingredients. It addresses optimisation strategies across multiple dimensions including precursor supply, metabolic stability, and synthetic regulatory circuits for scaled commercial production.
Topic tags
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