Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Assessing antimicrobial resistance connectivity across One Health sectors

Liguan Li, Bing Li, Xiaole Yin, Yu Xia, Yang Yu, Xiaoqing Xu, Tommy Tsan‐Yuk Lam, Kmy Leung, Fujie Xu, Xuxiang Zhang, Jianhua Guo, Heike Schmitt, Gerard D. Wright, Janet Midega, Cornelius Carlos Bezuidenhout, Renata Cristina Picão, Shaikh Ziauddin Ahammad, Kornelia Smalla, Steven P. Djordjevic, Amy Pruden, Peter J. Vikesland, Dominic Frigon, Fiona Walsh, Thomas U. Berendonk, Gianluca Corno, Despo Fatta‐Kassinos, Chang‐Jun Cha, Nicholas J. Ashbolt, Guang‐Guo Ying, Yi Luo, Yang Wang, Jianzhong Shen, Yu Zhang, Min Jae Yang, Xiangdong Li, Baolan Hu, Lizhong Zhu, Yongning Wu, Song Tang, Biao Kan, Yong‐Guan Zhu, Barth F. Smets, David W. Graham, Ryo Honda, Eddie Cytryn, Erica Donner, Per Halkjær Nielsen, Mark C.M. van Loosdrecht, Michael R. Gillings, William H. Gaze, Célia M. Manaia, Pedro J. J. Alvarez, Martin J. Blaser, Edward Topp, Tong Zhang

Nature Water · 2025

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Summary

This international collaborative review examines antimicrobial resistance as a systems problem spanning agriculture, aquaculture, clinical medicine and environmental compartments. The paper, as suggested by its title and author composition, maps the connectivity of AMR spread across One Health sectors to identify critical transmission pathways and inform integrated governance approaches. The work reflects growing recognition that agricultural antimicrobial use, particularly in livestock and aquaculture, represents a significant driver of resistance emergence with downstream human health consequences.

UK applicability

The findings are directly applicable to UK agriculture and public health policy, particularly given intensive livestock farming and aquaculture practices in the UK. The One Health connectivity perspective supports UK regulatory approaches to antimicrobial stewardship in veterinary and agricultural settings, and informs environmental monitoring strategies for resistant pathogens in waterways.

Key measures

Interconnections and transmission pathways of antimicrobial-resistant organisms and resistance genes across One Health sectors; prevalence and distribution of AMR in agricultural, aquatic and clinical environments

Outcomes reported

The study assessed pathways and connectivity of antimicrobial resistance (AMR) transmission across One Health sectors including agriculture, aquaculture, wastewater, clinical settings and the broader environment. The research appears to evaluate evidence for how AMR disseminates between farming systems and human health.

Theme
Policy, governance & rights
Subject
Antimicrobial resistance
Study type
Systematic Review
Study design
Systematic review
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Food supply chain
DOI
10.1038/s44221-025-00514-8
Catalogue ID
SNmok1w8ws-zl3gvj

Topic tags

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