Summary
This multicenter observational cohort study (DICE trial) characterised the epidemiology of diarrhoea in critically ill patients, a common but understudied complication of intensive care. The investigators examined incidence, risk factors, and clinical outcomes associated with diarrhoea, as suggested by the large international collaboration and comprehensive methodology. The findings are intended to inform clinical practice and future intervention studies targeting gastro-intestinal complications in critical illness.
UK applicability
The study includes United Kingdom investigator sites and data from UK intensive care units, making the findings directly applicable to UK critical care practice and guideline development. Results may inform nutritional support protocols and infection prevention strategies in NHS intensive care settings.
Key measures
Incidence and prevalence of diarrhoea during critical illness; duration and severity of diarrhoeal episodes; association with mortality, ventilator-associated pneumonia, and intensive care unit length of stay
Outcomes reported
The study examined the incidence, prevalence, characteristics, and clinical outcomes of diarrhoea in critically ill patients across multiple centres. It assessed associations between diarrhoea and patient morbidity, mortality, and length of stay in intensive care.
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