Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Mitochondrial dysfunction in lung ageing and disease

Suzanne M. Cloonan, Kihwan Kim, Pauline Estèves, Thomas Trian, Peter J. Barnes

European Respiratory Review · 2020

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Summary

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence of numerous new avenues of exciting mitochondria-related research including immunometabolism, mitochondrial transplantation and mitochondria-microbe biology. Since the early 1960s mitochondrial dysfunction has been observed in cells of the lung in individuals and in experimental models of chronic and acute respiratory diseases. However, it is only in the past decade with the emergence of more sophisticated tools and methodologies that we are beginning to understand how this enigmatic organelle regulates cellular homeostasis and contributes to disease processes in the lung. In this review, we highlight the diverse role of mitochondria in individual lung cell populations and what happens when these e

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1183/16000617.0165-2020
Catalogue ID
SNmotmpoqo-exsx7a
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