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Peer-reviewed

Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE)

Thomas Davies, Rob J. J. van Gassel, Marcel C.G. van de Poll, Jan Gunst, Michaël P. Casaer, Kenneth B. Christopher, Jean‐Charles Preiser, Aileen Hill, Kürşat Gündoğan, Annika Reintam Blaser, A. Rousseau, Carol Hodgson, Dale M. Needham, Martha Moreira Cavalcante Castro, Stefan J. Schaller, T. McClelland, Jeffrey J. Pilkington, Carla M. Sevin, Paul E. Wischmeyer, Zheng Lee, Deepak Govil, Andrew Li, Lee‐anne S. Chapple, Linda Denehy, Juan Carlos Montejo, Briana J. Taylor, Danielle E. Bear, Rupert M. Pearse, Angela McNelly, John R. Prowle, Zudin Puthucheary

Critical Care · 2022

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Summary

BACKGROUND: Clinical research on nutritional and metabolic interventions in critically ill patients is heterogenous regarding time points, outcomes and measurement instruments used, impeding intervention development and data syntheses, and ultimately worsening clinical outcomes. We aimed to identify and develop a set of core outcome domains and associated measurement instruments to include in all research in critically ill patients. METHODS: An updated systematic review informed a two-stage modified Delphi consensus process (domains followed by instruments). Measurement instruments for domains considered 'essential' were taken through the second stage of the Delphi and a subsequent consensus meeting. RESULTS: In total, 213 participants (41 patients/caregivers, 50 clinical researchers and 1

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1186/s13054-022-04113-x
Catalogue ID
SNmotmpoqo-xfnmvf
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