Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Impact of COVID-19 on the Endocrine System: A Mini-review

Sophie Clarke, Ali Abbara, Waljit S. Dhillo

Endocrinology · 2021

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Summary

The coronavirus disease 2019 (COVID-19) pandemic continues to exert a significant impact on global health care systems, causing devastating mortality and morbidity. As time passes and our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond that of the respiratory system. The coronavirus responsible for COVID-19, severe acute respiratory syndrome coronavirus 2, obtains cellular access through the angiotensin-converting enzyme 2 (ACE2) receptor in a process requiring the transmembrane serine protease 2 (TMPRSS2) protein. Both ACE2 and TMPRSS2 are widely expressed in many endocrine glands. This, along with several case reports of thyroid and pituitary disruption in patients with COVID-19, has resulted in significant interest in its im

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1210/endocr/bqab203
Catalogue ID
SNmotmpttk-szg8gd
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