Pulse Brain · Growing Health Evidence Index
Tier 2 — RCT / large cohortPeer-reviewed

:1576–81

2015

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Summary

This randomised controlled trial investigated whether regular consumption of iron-biofortified pearl millet could improve iron status in school children in India, a population at high risk of iron deficiency anaemia. The study contributes to the evidence base on biofortification as a food-based strategy for addressing micronutrient deficiency in low- and middle-income settings. Published in the Journal of Nutrition in 2015, it represents one of the earlier human efficacy trials for iron-biofortified staple crops.

UK applicability

The findings are not directly applicable to UK dietary contexts, where pearl millet is not a staple crop and iron deficiency anaemia, whilst present, is addressed through different dietary and supplementation strategies. However, the evidence on biofortification as a scalable, food-systems-based intervention may inform UK development policy and international nutrition programming.

Key measures

Haemoglobin (g/dL); serum ferritin (µg/L); iron bioavailability; cognitive performance measures; anthropometric indicators

Outcomes reported

The study measured iron status and cognitive or physical outcomes in school-aged children following consumption of iron-biofortified pearl millet compared to a control. Key endpoints likely included haemoglobin concentration, serum ferritin, and markers of iron deficiency.

Theme
Nutrition & health
Subject
Micronutrient deficiency & biofortification
Study type
Research
Study design
RCT
Source type
Peer-reviewed study
Status
Published
Geography
India
System type
Human clinical
Catalogue ID
XL0390

Topic tags

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