Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Genetic diversity and disease: The past, present, and future of an old idea

Amanda K. Gibson

Evolution · 2021

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Summary

This perspective piece synthesises the historical development and contemporary evidence for the hypothesis that genetic diversity confers disease resistance across host populations. Drawing on overlapping frameworks from evolutionary biology, agriculture, and conservation, Gibson examines where this principle has been applied and proposes that monitoring, preserving, and augmenting genetic diversity represents a key evolutionarily informed strategy for buffering wild, domesticated, and human populations against future disease outbreaks.

UK applicability

The findings have potential relevance to UK agricultural policy and disease management strategies, particularly for livestock breeding programmes and crop diversity conservation. The principles may inform approaches to biosecurity and resilience-building in both livestock and crop production systems.

Key measures

Disease severity and parasitism rates in relation to host genetic diversity; experimental tests of the diversity–disease relationship

Outcomes reported

The paper synthesises evidence demonstrating that genetically homogeneous host populations experience more severe parasitism than genetically diverse populations. It examines applications of this principle across wild, domesticated, and human populations, and proposes strategies for leveraging genetic diversity to mitigate future disease outbreaks.

Theme
Climate & resilience
Subject
Animal health & welfare
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Laboratory / in vitro
DOI
10.1111/evo.14395
Catalogue ID
SNmoqqrs7c-8oz19d

Topic tags

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