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Peer-reviewed

Multi-ethnic genome-wide association study for atrial fibrillation

Carolina Roselli, Mark Chaffin, Lu‐Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Álvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Cappola, John F. Carlquist, Daniel I. Chasman, Lin Y. Chen, Yii-Der Ida Chen, Eue‐Keun Choi, Seung Hoan Choi, Ingrid E. Christophersen, Mina K. Chung, John W. Cole, David Conen, James P. Cook, Harry J. Crijns, Michael J. Cutler, Scott M. Damrauer, Brian R. Daniels, Dawood Darbar, Graciela Delgado, Joshua C. Denny, Martin Dichgans, Marcus Dörr, Elton Dudink, Samuel C. Dudley, Nada Esa, Tōnu Esko, Markku Eskola, Diane Fatkin, Stephan B. Felix, Ian Ford, Oscar H. Franco, Bastiaan Geelhoed, Raji P. Grewal, Vilmundur Guðnason, Xiuqing Guo, Namrata Gupta, Stefan Gustafsson, Rebecca Gutmann, Anders Hamsten, Tamara B. Harris, Caroline Hayward, Susan R. Heckbert, Jussi Hernesniemi, Lynne J. Hocking, Albert Hofman, Andréa R. V. R. Horimoto, Jie Huang, Paul L. Huang, Jennifer E. Huffman, Erik Ingelsson, Esra Gücük İpek, Kaoru Ito, Jordi Jiménez‐Conde, Renée Johnson, J. Wouter Jukema, Stefan Kääb, Mika Kähönen, Yoichiro Kamatani, John P. Kane, Adnan Kastrati, Sekar Kathiresan, Petra Katschnig‐Winter, Maryam Kavousi, Thorsten Kessler, Bas Kietselaer, Paulus Kirchhof, Marcus E. Kleber, Stacey Knight, José Eduardo Krieger, Michiaki Kubo, Lenore J. Launer, Jari Laurikka, Terho Lehtimäki, Kirsten Leineweber, Rozenn N. Lemaître, Man Li, Hong Euy Lim, Henry J. Lin, Honghuang Lin

Nature Genetics · 2018

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Summary

Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identifi

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1038/s41588-018-0133-9
Catalogue ID
SNmp99jfkz-etqawa
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