Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Haemoglobin thresholds to define anaemia from age 6 months to 65 years: estimates from international data sources

Sabine Braat, Katherine Fielding, Jiru Han, Victoria E. Jackson, Sophie Zaloumis, Jessica Xu, Gemma Moir-Meyer, Sophia M. Blaauwendraad, Vincent W. V. Jaddoe, Romy Gaillard, Patricia C. Parkin, Cornelia M. Borkhoff, Charles Keown‐Stoneman, Catherine S. Birken, Jonathon L. Maguire, Melanie Bahlo, Eliza M. Davidson, Sant‐Rayn Pasricha

The Lancet Haematology · 2024

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Summary

BACKGROUND: Detection of anaemia is crucial for clinical medicine and public health. Current WHO anaemia definitions are based on statistical thresholds (fifth centiles) set more than 50 years ago. We sought to establish evidence for the statistical haemoglobin thresholds for anaemia that can be applied globally and inform WHO and clinical guidelines. METHODS: In this analysis we identified international data sources from populations in the USA, England, Australia, China, the Netherlands, Canada, Ecuador, and Bangladesh with sufficient clinical and laboratory information collected between 1998 and 2020 to obtain a healthy reference sample. Individuals with clinical or biochemical evidence of a condition that could reduce haemoglobin concentrations were excluded. We estimated haemoglobin th

Subject
Other / interdisciplinary
Source type
Peer-reviewed study
System type
Other
DOI
10.1016/s2352-3026(24)00030-9
Catalogue ID
SNmpdjw7j2-aqb4gd
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