Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Inflammatory parameters mediates the relationship between dietary index for gut microbiota and frailty in middle-aged and older adults in the United States: findings from a large-scale population-based study

Qijiang Yang, Xiaoyun Wu, Jinlan Duan, Yi‐Yin Chen, Tianrui Yang

Frontiers in Nutrition · 2025

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Summary

Background Frailty is a prevalent geriatric syndrome marked by diminished physiological reserves and heightened vulnerability to stressors, leading to adverse health outcomes and imposing significant economic burdens on healthcare systems. Methods This study investigates the relationship between the Dietary Index for Gut Microbiota (DI-GM) and the risk of frailty in middle-aged and older adults, using data from the National Health and Nutrition Examination Survey (NHANES) collected from 2007 to 2018. Weighted logistic regression, subgroup analysis, and restricted cubic splines (RCS) were performed to evaluate the relationship between DI-GM and frailty risk. Additionally, a mediation analysis was conducted to investigate the influence of relevant inflammatory parameters from complete blood

Subject
Gut microbiome & human health
Source type
Peer-reviewed study
System type
Other
DOI
10.3389/fnut.2025.1553467
Catalogue ID
SNmpdjwg34-74ogd9
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