Pulse Brain · Growing Health Evidence Index
Peer-reviewed

The Impact of Diet and Nutrition on the Gut-Liver Axis in Cirrhosis and Hepatic Encephalopathy

Muhammad Hassan, Richard Bakalov, S M Abdel Baset, Pooja Shethna, Dhruti Patel, Andrea Weitoschova, Naqiyah Qadir, Raquel Batista

Journal of Biosciences and Medicines · 2025

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Summary

Background & Objective: Cirrhosis, the end stage of chronic liver disease, is associated with high morbidity and mortality worldwide. Central to its progression is the gut-liver axis, a bidirectional communication system between the gut microbiota and the liver. Disruption of this axis, including gut barrier dysfunction, small intestinal bacterial overgrowth (SIBO), and microbial dysbiosis, contributes to liver injury, systemic inflammation, and complications such as hepatic encephalopathy (HE). This review synthesizes current evidence on the impact of diet and nutrition on the gut-liver axis, focusing on dietary interventions, probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT). Methods: A structured narrative review was conducted using PubMed, Embase, Cochrane

Subject
Gut microbiome & human health
Source type
Peer-reviewed study
System type
Other
DOI
10.4236/jbm.2025.1310022
Catalogue ID
SNmpdjwg34-mcx33e
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