Summary
Objective To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Methods We followed 49,493 women from the Nurses9 Health Study (NHS) (1984–2006) and 27,842 men from the Health Professionals Follow-Up Study (HPFS) (1986–2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent SCD. For the NHS, long-term average dietary intake was calculated from 7 repeated semiquantitative food frequency questionnaires (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from 5 repeated SFFQs, and SCD was assessed in 2008 and 2012. Results Higher intake of total flavonoids was associated with lower odds of SCD after adjustment for age, total energy intake, major nondietary factors, and specific dietary factors. In a comparison of the highest vs the lowest quintiles of total flavonoid intake, the pooled multivariable-adjusted odds ratio (OR) of 3-unit increments in SCD was 0.81 (95% confidence interval [CI] 0.76, 0.89). In the pooled results, the strongest associations were observed for flavones (OR 0.62 [95% CI 0.57, 0.68]), flavanones (0.64 [0.58, 0.68)]), and anthocyanins (0.76 [0.72, 0.84]) ( p trend Conclusion Our findings support a benefit of higher flavonoid intakes for maintaining cognitive function in US men and women.
Outcomes reported
Objective To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Results Higher intake of total flavonoids was associated with lower odds of SCD after adjustment for age, total energy intake, major nondietary factors, and specific dietary factors. Source report: What Your Food Ate — Montgomery & Biklé (2022), ch.9: OVERLOOKED GEMS Ref#: WYFA-0385 Original: Yeh, T.-S., et al. 2021. Long-term dietary flavonoid intake and subjective cognitive decline in US men and women. Neurology 97:e1041–e1056.
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