Summary
This narrative review published in Signal Transduction and Targeted Therapy consolidates contemporary understanding of the molecular biology underpinning ageing and age-related pathologies. The authors examine established hallmarks of ageing and discuss potential clinical interventions targeting these mechanisms, bridging fundamental gerontological research with translational opportunities for disease prevention and therapeutic development.
Regional applicability
The mechanistic insights and therapeutic strategies reviewed are broadly applicable to UK clinical practice and biomedical research, though the review does not address UK-specific epidemiological patterns or healthcare policy frameworks for managing ageing populations.
Key measures
Molecular and cellular markers of ageing; hallmarks of ageing; therapeutic targets and interventions
Outcomes reported
The review synthesises molecular mechanisms driving ageing and age-related diseases, examining cellular hallmarks including genomic damage, mitochondrial dysfunction, and loss of cellular homeostasis. It evaluates evidence-based therapeutic approaches and interventions targeting these fundamental ageing processes.
Topic tags
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