Pulse Brain · Growing Health Evidence Index
Peer-reviewed

An atlas of genetic scores to predict multi-omic traits

Yu Xu, Scott C. Ritchie, Yujian Liang, Paul R. H. J. Timmers, Maik Pietzner, Loïc Lannelongue, Samuel A. Lambert, Usman A. Tahir, Sebastian May-Wilson, Carles Foguet, Åsa Johansson, Praveen Surendran, Artika P. Nath, Elodie Persyn, James E. Peters, Clare Oliver‐Williams, Shuliang Deng, Bram P. Prins, Jian’an Luan, Lorenzo Bomba, Nicole Soranzo, Emanuele Di Angelantonio, Nicola Pirastu, E Shyong Tai, Rob M. van Dam, Helen Parkinson, Emma E. Davenport, Dirk S. Paul, Christopher Yau, Robert E. Gerszten, Anders Mälarstig, John Danesh, Xueling Sim, Claudia Langenberg, James F. Wilson, Adam S. Butterworth, Michael Inouye

Nature · 2023

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Summary

to identify disease associations using a phenome-wide scan. We highlight a series of biological insights with regard to genetic mechanisms in metabolism and canonical pathway associations with disease; for example, JAK-STAT signalling and coronary atherosclerosis. Finally, we develop a portal ( https://www.omicspred.org/ ) to facilitate public access to all genetic scores and validation results, as well as to serve as a platform for future extensions and enhancements of multi-omic genetic scores.

Source type
Peer-reviewed study
DOI
10.1038/s41586-023-05844-9
Catalogue ID
SNmoj1yirq-dd2gs8
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