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Tier 4 — Narrative / commentaryGuideline

2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes

Sunil V. Rao, Michelle L. O’Donoghue, Marc Ruel, Tanveer Rab, Jaqueline E. Tamis-Holland, John H. Alexander, Usman Baber, Heather Baker, Mauricio G. Cohen, Mercedes Cruz-Ruiz, Leslie L. Davis, James A. de Lemos, Tracy A. DeWald, Islam Y. Elgendy, Dmitriy N. Feldman, Abhinav Goyal, Ijeoma Isiadinso, Venu Menon, David A. Morrow, Debabrata Mukherjee, Elke Platz, Susan B. Promes, Sigrid Sandner, Yader Sandoval, Rachel Schunder, Binita Shah, Jason P. Stopyra, Amy W. Talbot, Pam R. Taub, Marlene S. Williams, Hani Jneid, Craig J. Beavers, Theresa M. Beckie, Jim Blankenship, Deborah B. Diercks, Bernard Lo, Clauden Louis, Faisal M. Merchant, Noreen T. Nazir, Derek So, Matthew I. Tomey, Frederick G.P. Welt

Journal of the American College of Cardiology · 2025

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Summary

This 2025 consensus guideline from the American College of Cardiology, American Heart Association, and affiliated professional societies provides evidence-graded recommendations for the diagnosis and management of acute coronary syndromes. The guideline synthesises current evidence to inform clinical decision-making across diverse acute care settings in the United States, covering diagnostic protocols, pharmacological and invasive interventions, risk stratification, and conservative management approaches. As a consensus document, it reflects current best practice rather than original research findings.

Regional applicability

This guideline is based on United States clinical evidence and healthcare systems, with limited direct applicability to United Kingdom practice. However, core diagnostic and therapeutic principles may inform UK clinical guidance; notable differences exist in healthcare infrastructure, access to interventions, and regulatory frameworks that would require adaptation for UK implementation.

Key measures

Not applicable; this is a consensus guideline rather than an empirical study.

Outcomes reported

This guideline synthesises evidence-based recommendations for diagnosis, risk stratification, and management of acute coronary syndromes across acute care settings. It does not report original research outcomes but rather provides standardised clinical guidance for healthcare professionals.

Theme
Policy, governance & rights
Subject
Out of scope / non-food
Study type
Guideline
Study design
Guideline
Source type
Guideline
Status
Published
Geography
United States
System type
Human clinical
DOI
10.1016/j.jacc.2024.11.009
Catalogue ID
SNmp6e6lsi-n4d14d

Topic tags

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