Summary
This 2022 international narrative review examines the molecular and biochemical basis of obesity aetiology, integrating evidence from toxicology, metabolism, and endocrinology. The authors synthesise research on dysregulated metabolic signalling, endocrine dysfunction, and potential environmental chemical contributions to obesity development. The work is positioned primarily within basic science and disease mechanism literature rather than food systems or agricultural contexts.
Regional applicability
As a review of fundamental molecular mechanisms of obesity, findings are broadly applicable to United Kingdom clinical and public health contexts, though the paper does not focus on food system or dietary quality factors amenable to agricultural intervention.
Key measures
Dysregulated metabolic signalling pathways, endocrine dysfunction markers, environmental chemical exposure associations with obesity risk
Outcomes reported
The review synthesises multidisciplinary evidence on molecular and biochemical mechanisms contributing to obesity development, integrating perspectives from toxicology, metabolism, and endocrinology.
Topic tags
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