Summary
This 2025 narrative review integrates molecular and cellular mechanisms through which sedentary behaviour contributes to cardiometabolic disease risk, examining inflammatory cascades and metabolic dysfunction. The authors bridge molecular-level evidence with clinical outcomes to inform prevention and intervention strategies. The scope does not directly address agricultural systems, food composition, or farming practices.
Regional applicability
As a mechanistic review focused on cellular and systemic pathways, findings are likely applicable across high-income populations including the United Kingdom, though the review does not address dietary or food-system variables that might interact with activity patterns in UK health outcomes.
Key measures
Cellular signalling pathways, inflammatory markers, metabolic dysfunction endpoints, cardiometabolic disease risk factors
Outcomes reported
The review synthesises mechanistic evidence linking sedentary behaviour to cardiometabolic disease risk by examining cellular signalling pathways, systemic inflammatory cascades, and metabolic dysfunction.
Topic tags
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