Summary
This observational study of 3,666 patients from the OCEAN-Mitral registry examined how changes in tricuspid regurgitation before and after mitral transcatheter edge-to-edge repair affect clinical outcomes. Post-procedural tricuspid regurgitation, particularly new-onset disease, was independently associated with increased risk of cardiovascular death or heart failure hospitalisation (adjusted hazard ratio 1.83 for new-onset, 1.45 for residual), whereas baseline tricuspid regurgitation severity was not prognostically significant. The findings suggest that post-procedural tricuspid regurgitation assessment is clinically important for patient management following mitral repair procedures.
Regional applicability
This is a Japanese multicentre registry study and findings reflect clinical practices and populations in Japan. The procedural techniques and patient demographics may differ from United Kingdom practice; transferability would depend on similar patient selection criteria, operator experience, and echocardiographic assessment standards in UK centres performing transcatheter mitral repair.
Key measures
Baseline and post-procedure tricuspid regurgitation severity (≥moderate defined as significant), tricuspid regurgitation pressure gradient, cardiovascular death, heart failure hospitalisation, tricuspid annulus diameter, atrial fibrillation incidence
Outcomes reported
The study examined the association between periprocedural change in tricuspid regurgitation and cardiovascular outcomes (cardiovascular death or heart failure hospitalisation) in patients undergoing mitral transcatheter edge-to-edge repair. Tricuspid regurgitation pressure gradient changes were also evaluated as a secondary measure.
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