Summary
This case-control genetic study of 5,242 coronary artery disease patients (2,099 genotyped) identified two single-nucleotide polymorphisms associated with restenosis risk following revascularisation. The PHACTR1 rs9349379 variant showed heightened association in women and diabetic patients, whilst the LPL rs264 variant was associated with increased restenosis risk in men. Dyslipidemia emerged as the dominant modifiable metabolic risk factor, with an odds ratio of 2.14 overall and 2.32 in men.
Regional applicability
The study cohort geography is not explicitly specified in the abstract; without confirmation of United Kingdom or European population origin, the generalisability to United Kingdom coronary artery disease populations cannot be established. Findings may inform personalised risk stratification in UK cardiology if the cohort demographics align with local populations.
Key measures
Odds ratios for restenosis risk; genetic association analysis via PLINK 1.9; stratification by sex, diabetes status, hypertension, and dyslipidemia
Outcomes reported
The study identified genetic variants (rs9349379 in PHACTR1 and rs264 in LPL) associated with increased restenosis risk following coronary revascularisation, with sex- and diabetes-dependent associations. Dyslipidemia emerged as a major modifiable risk factor for restenosis, particularly in men.
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