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Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Social determinants of mental health in major depressive disorder: Umbrella review of 26 meta-analyses and systematic reviews

Noy Alon, Natalia Macrynikola, Dylan J. Jester, Matcheri S. Keshavan, Charles F. Reynolds, Shekhar Saxena, Michael L. Thomas, John Torous, Dilip V. Jeste

Psychiatry Research · 2024

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Summary

This umbrella review synthesised 26 meta-analyses and systematic reviews to map relationships between social determinants and major depressive disorder. The work integrates secondary literature on how socioeconomic, environmental, and psychosocial factors shape depression aetiology and population burden. As a methodology paper consolidating meta-analytical evidence, it provides a structured evidence base on the social context of depression, though the specific effect sizes and strength of individual associations remain uncertain without access to the full text.

Regional applicability

The applicability to United Kingdom conditions depends on the geographic scope and populations represented in the 26 included reviews; without the full text, it is unclear whether UK-specific evidence is well-represented. If predominantly sourced from high-income country contexts, findings may generalise to UK mental health policy and practice, but consideration of cultural and structural differences in social determinants would be warranted.

Key measures

Effect sizes and evidence quality from included meta-analyses and systematic reviews on social determinants of major depressive disorder

Outcomes reported

The review synthesised evidence on relationships between social determinants (socioeconomic, environmental, and psychosocial factors) and major depressive disorder aetiology and burden. It consolidated findings from 26 existing meta-analyses and systematic reviews to map the social context of depression.

Theme
Policy, governance & rights
Subject
Out of scope / non-food
Study type
Umbrella Review
Study design
Umbrella review
Source type
Peer-reviewed study
Status
Published
System type
Human clinical
DOI
10.1016/j.psychres.2024.115854
Catalogue ID
SNmpxjxxil-vsgmfr

Topic tags

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